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Mutations in BRAF, most commonly BRAF V600E , drive the development of various cancers, including melanoma, lung cancer, and thyroid cancer, and its carcinogenic signal transmission requires copper to bind to MEK and facilitate the activation of ERK1/2

It is well established that cap-independent translation of ATF4 requires eIF2, which is activated by endoplasmic reticulum (ER), oxidative, or mitochondrial stress 42,43,44

doi: 10.1369/jhc.5A6840.2006

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