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Preclinical: In a preliminary preclinical study in a 6-hydroxydopamine (6-OHDA) rat lesion model, rodents were pretreated with 10, 50, or 150 g IN-GDNF prior to unilateral 6-OHDA injections

Reduction of Beclin1 impairs adaptive remodeling, whereas excessive Beclin1 promotes autophagy beyond beneficial levels and exacerbates adverse remodeling

Here we describe two complementary modes of mitochondrial support: a baseline mode, in which mitochondria sustain circuit architecture and physiological properties over long timescales, and an activity-evoked mode, in which local mitochondrial outputs support synaptic transmission and plasticity

Pretreatment with SFN in rats could prevent hepatic damage induced by cisplatin and the decrease of antioxidant enzyme activity as well as mitochondrial alterations in oxygen consumption were also attenuated (Gaona-Gaona et al., 2011)

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