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References 1.Rockstroh JK

Fakhar-e-Alam: Conceptualization, Investigation, Validation, Supervision, Project administration, Writing review & editing

When microglia remain activated for an extended period, the production of mediators is sustained longer than usual and this increase in mediators contributes to loss of synaptic connections and neuronal cell death

doi:10.3945/ajcn.2009.27462F

Debasmita B, Raj C, Ishan A, Ipsita D

First principles for therapy design Therapy design should follow three first principles: target the source before the sink, prioritizing isoform- or site-specific modulation of NOX enzymes, mitochondrial ROS sites, ER oxidoreductases, or iron handling rather than indiscriminate scavenging that can blunt physiological signalling (Sies et al