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Mutations in the kinase domain involving Y123D and Y1230C are majorly involved in the activation of the receptor in HNSCC [86]

Certain populations, including older adults and people following a vegan diet, are at a higher risk of vitamin B12 deficiencies and may benefit from taking a vitamin B12 supplement

*Correspondence: Nikolaos Kokras, [email protected] This article was submitted to Behavioral Endocrinology, a section of the journal Frontiers in Behavioral Neuroscience Disclaimer All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers

Completed human trials establishing safety and efficacy would enable consideration for approval pathways

And if you had the MTHFR gene variant (which affects how your body processes B12 and folate, present in roughly 10-15% of the population), taking the wrong form of B12 may not address the underlying issue efficiently anyway