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Receptors have time to reset between signals, potentially maintaining sensitivity over longer treatment periods

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This abnormality results from intricate metabolic reprogramming, which is not thoroughly investigated

As Howe et al[69] pointed out, this negative effect may be explained by the low bioavailability of IGF-I within the brain parenchyma

9 BhattacharjeeA.PrajapatiS

For instance, during ophthalmic surgery, the use of bovine collagen-derived products such as corneal shields and catgut suture material led to conjunctival edema in two patients [87]