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The prescription of certain VGSC-inhibiting drugs already in clinical use, such as antiepileptic drugs and antiarrhythmic agents, has been associated with reduced cancer incidence and improved survival in retrospective studies (329, 330)

Butyrate is absorbed and utilized in the proximal colon by epithelial cells and acts as the preferred energy source for colonocytes, whereas other absorbed SCFAs reach peripheral circulation to a varying degree (11)

10.3389/fphar.2021.730525 Front Pharmacol

Standardized to contain 80% Silymarin) (Seed/Fruit)

Reactive oxygen species mediate cytokine activation of c-Jun NH2-terminal kinases

Funding This study was supported by Key Research and Development Program of Shaanxi (NO.2018ZDCXL-SF-01-02-01)