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Insulin receptor isoforms and insulin receptor/insulin-like growth factor receptor hybrids in physiology and disease

8 Glutathione (GSH) is a crucial intracellular antioxidant, a tripeptide (-glutamyl-cysteinyl-glycine) (Figure 1), and plays a key role in maintaining cellular redox balance

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The neurotoxicity of 5- S -cysteinyl catecholamines may be due to their further oxidation to benzothiazine species, such as DHBT-1 (dihydrobenzothiazine-1-(2-aminoethyl)-3,4-dihydro-5-hydroxy-2 H -1,4-benzothiazine-3-carboxylic acid) (Shen et al., 1996, Shen et al., 1997, Vauzour et al., 2008)

Copper is widely distributed in the body, primarily in the skeleton, liver, and kidneys (19)