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In both ME/CFS and HC, lower baseline levels of 12,13-diHOME correlated with higher Multidimensional Fatigue Inventory (MFI) scores of physical fatigue and reduced activity 61

A population-level study in India found curcumin intake up to 100 mg/day safe and associated with reduced cancer prevalence (Jutooru et al., 2010) FAO/WHO Joint Expert Committee on Food Additives (JECFA) considers 4 to 10 g of turmeric daily safe for healthy adults (Kocaadam and Sanlier, 2017)

A personalized evaluation with your provider may include these markers alongside genetic predisposition data to inform treatment decisions

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Together, these shifts create a metabolic environment that substantially increases vulnerability to cardiometabolic disease (Van der Leeuw et al., 2013)