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These effects may be due to the unique localization of CD38 within specific membrane domains of effector cells

PadmanabhanSWalyMITaranikantiVGuizaniNAliARahmanMSet al

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By mapping the extra-parasitic metabolites from iPfa to the cytosolic metabolites from the hepatocyte model, we found that from the 241 nutrients that the parasite can transport, 165 ( Table S1 ) are present in the cytosol of the liver model

To further expound on the fire metaphor, the result of not being able to neutralize the effects of ROS, is damage and, also, inflammation (literally the body is in flames)