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To view a copy of this licence, visit About this article Cite this article Chen, Y., Jiang, Z

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Abstract Introduction: Lipopolysaccharide (LPS), a constituent of the outer membrane of Gram-negative bacteria, is a powerful inducer of systemic inflammation and has been extensively utilized in experimental models to simulate inflammatory responses and septic disorders

The current challenge is to understand the temporal and spatial interactions among these cell death pathways and to identify context-specific targets that can be safely and effectively modulated in patients

Varuzhanyan, G