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Previous studies have shown that a small molecule called Ras Lethal 3 ((1S,3R)-RSL3,(RSL3)) can pharmacologically inhibit GPX4 in skin and soft tissue cancer models in vitro and leads to induction of ferroptosis 10,11

Microsurg (1999) 19(8):37480

Charting differentially methylated regions in cancer with Rocker-meth Commun Biol 4, 1249 (2021)

However, human clinical trials demonstrating sustained tissue accumulation and functional antioxidant benefit remain sparse, making real-world efficacy difficult to quantify

In the presence of GSH, GPX4 mediates the conversion of toxic LPOs to nontoxic lipid alcohols

doi: 10.1002/ajmg.b.32662 73 KrzyciakWBystrowskaBKarczPChrzanRBryllATurekAet al