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The landscape of infective endocarditis (IE) has undergone significant changes in recent years in terms of the affected population, which is increasingly elderly, and about the implicated pathogens, often identified as Staphylococci and Enterococci

Melanotan II produces melanogenesis by activation of the MC1 receptor , whereas its clinically documented sexual effects are thought to be related to its ability to activate the MC4 receptor (though the MC3 is thought to also possibly be involved)

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