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272 : 29362941 Tanaka T, Hosoi F, Yamaguchi-Iwai Y, Nakamura H, Masutani H, Ueda S, Nishiyama A, Takeda S, Wada H, Spyrou G and Yodoi J (2002) Thioredoxin-2 (TRX-2) is an essential gene regulating mitochondria-dependent apoptosis

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Phospholipolysis is a vital source of arachidonic acid in neutrophils, and phospholipase and sphingomyelinase activity, which produce endogenous lipid mediators from membrane phospholipids, are closely associated with normal apoptosis progression (125)

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Melatonins free radical scavenging properties and its ability to easily pass the BBB suggest that it may be neuroprotective (Antolin et al., 2005)