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Several studies using HCC cell lines suggests that ferroptosis may serve as the principal mechanism underlying the anticancer effect of sorafenib via suppressing the cystine/glutamate antiporter SLC7A11 [94,95,96]

Although this study provided great evidences for identifying potential diagnostic and therapeutic target in retinoblastoma, further exploration was in demand
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It also upregulates the transcription of IL-1, IL-18, and TNF-, forming positive feedback
