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Furthermore, MOTS-c plays the role of endocrine-like factors by regulating nuclear transcription to restore homeostasis

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[8] Intranasal Peptide Administration Intranasal administration can bypass some aspects of gastrointestinal degradation by exploiting the nasal mucosa for absorption

Indeed, chemical sympathectomy has been recently shown to alleviate the inflammatory response following chronic sleep deprivation in mice 255 , and both - and, to a lesser extent, -adrenergic receptors seem to contribute to the sympathetic regulation of inflammatory responses to sleep deprivation 256
