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At an acidic pH, propeptide elimination can happen auto- or trans-catalytically (Pritsch et al., 2020
Iron regulatory proteins secure mitochondrial iron sufficiency and function
Growth of surgically confirmed leiomyomas in postmenopausal women: analysis of the influencing factors

It also contributes to good liver function

[0452] Thus, in various embodiments the linker can be stable (non-cleavable) or hydrolysable (cleavable), whereby it is released following cellular entry

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