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The clinical signal began with a phase 1b study showing that concomitant cagrilintide plus semaglutide 2.4 mg was well tolerated in healthy volunteers, [6] and a phase 2 trial in people with type 2 diabetes and overweight, where CagriSema produced numerically greater weight loss (~15.6%) than semaglutide (~5.1%) or cagrilintide (~8.1%) alone