5-amino-1mq mechanism of action nnmt inhibitor Selective and membrane-permeable small molecule inhibitors nicotinamide N-methyltransferase reverse high fat diet-induced obesity in mice Mechanisms and inhibitors of nicotinamide
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It depends on how bad your deficiency is and how you react to treatment

If you are pursuing performance or physique goals in a competitive setting, consider WADA-compliant alternatives such as Cardarine (GW-501516) for endurance or AOD-9604 for fat loss both of which should still be verified for status with your sports anti-doping authority
Mol Hum Reprod

Heres a table to help understand B12 dosages for different groups: Women over 50 might need more B12, up to 1000 mcg a day

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A 2025 study in Biomolecules found that NNMT inhibitor treatment "reduces body weight, white adipose tissue mass, total cholesterol, and adipocyte size in obese mice." These changes suggest cardiovascular benefit beyond simple weight loss
