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182 RamlackhansinghA.BrooksD.GreenwoodR.BoseS.TurkheimerF.KinnunenK.et al (2011)

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Metabolic tracing studies confirm that GLU-derived -KG is the predominant precursor for L -2HG formation in hypoxia (93)

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For the correct progression of the metabolic pathways in which this amino acid participates (remethylation and trans-sulphuration), the presence of cofactors is necessary