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Edge activators cause lipid vesicles bilayer membrane to become less stable, become more deformable, and facilitate vesicles passage through the skins micropores while avoiding the stratum corneum barrier, which is the primary barrier and rate-limiting step for drug diffusion through the skin (163, 164)

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doi: 178/7/4641 [pii] [DOI] [PMC free article] [PubMed] [Google Scholar] 13.Ma TY, Iwamoto GK, Hoa NT, Akotia V, Pedram A, Boivin MA, Said HM