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DEM at the concentration of 0.5 mM, 1 mM, or 2 mM was added into the dark-incubated unsynchronized cultures (G 0 ) one hour before switching to light (at the time point of T-1, Figure 4A) to minimize cell cycle-associated glutathione fluctuation (Fang et al., 2014)

Inherited Disorders of the -Glutamyl Cycle At least two genetic enzyme defects lead to the overproduction of 5-oxoproline

GSH serves as a nucleophilic co-substrate of detoxification enzymes such as glutathione S-transferases (GST) in detoxifying xenobiotics 5,6

Compared to control serum, GHK-Cu reduced wrinkle volume 55.8% and wrinkle depth 32.8% [20]

Once Korsakoffs syndrome appears, thiamine supplementation is successful in only half of the patients

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