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If it is severe enough to interfere with daily functioning, some providers recommend extending Phase 2 by an additional two to four weeks rather than escalating on schedule

Effective therapeutic paradigms appear to converge on modulation of the mitochondrial function, purinergic signaling, and neuroinflammation, often supplemented by nutritional regulators such as vitamin D and retinoids

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In HF, increased fission reduces ATP production, while in AD, impaired fusion affects synaptic mitochondrial function

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