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Genetic and pharmacologic NNMT suppression reduces adiposity and improves metabolic readouts in preclinical models, with supportive cellular data showing increases in NAD and SAM and suppression of lipogenesis
Moreover, neither depletion nor overexpression of CSE significantly affected overall Cys and GSH levels (Extended Data Fig
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This comprehensive analysis offers valuable insights that could propel further research and innovation in the field of neurology, making it essential reading for experts interested in the molecular mechanisms underlying brain function and disease
