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When neurological symptoms are present, more intensive treatment is required: 1 mg hydroxocobalamin on alternate days until no further improvement occurs, followed by maintenance therapy every two months

Renal impairment reduces B12 excretion, leading to accumulation

Gastrointestinal discomfort such as nausea or upset stomach

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These observations are thought to be linked to a rise in the activity of lipolytic beta-3 adrenergic receptors, hinting that the peptide's actions could be connected to the beta-adrenergic pathway