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The initial discomfort represents a transition period, not a permanent feature of the protocol

In this study, intestinal barrier function was found to be diminished before onset of arthritis in mice

All the authors who have proposed a diagnostic algorithm for histamine intolerance emphasize the need to initially rule out other potential causes of symptoms associated with an increase in plasma histamine [10,13,54]

S.LeiL.GillS.et al (2002)

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The scientists found that the mice not receiving vitamin E exhibited evidence of oxidative injury to their kidneys and testis, whereas those organs appeared normal in mice receiving vitamin E
