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The mutations can affect follicular development, normal hair cycling and hair fiber fragility

It promotes JNK phosphorylation of c-Jun and stimulates the proliferation of normal hematopoietic cells and/or apoptosis of malignant cells (Figure 8B) [22,175]

The DEGs up-regulated in each metabolic phenotype shared by at least 4 out of 5 patient MPE samples were enriched by Enrichr algorithm 42 against curated databases including BioCarta, WikiPathways, NCI-Nature Pathway, Gene Ontology (GO) cellular components and GO Biological process, respectively (Supplementary Data 5)

In conclusion, the experimental data are well described by the model for all knock-downs, except for slight deviations for siKEAP1, where the increase in Keap1-GFP and Srxn1-GFP after DEM exposure was underestimated by the model

Similarly, the dexamethasone cohort comprised patients who received drugs belonging to ATC code H02AB02 (Supplementary Table S1), and the patients who received dexamethasone for only topical usage were excluded

This reflects a desire for clear dose-to-volume relationships in metabolic studies