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Although fumarate has been demonstrated to exert a pivotal role in cellular metabolism and signaling, further research is necessary to elucidate the intricate interactions between fumarate, the TCA cycle, mtDNA, and neuronal functioning

doi: 10.1111/j.1523-5378.2007.00525.x

Farnesoid X Nuclear Receptor Ligand Obeticholic Acid for Non-Cirrhotic, Non-Alcoholic Steatohepatitis (FLINT): A Multicentre, Randomised, Placebo-Controlled Trial

To investigate whether S-nitrosylation of MYCN at specific cysteine residues contributes to NO-mediated suppression of ER stress in NEPC, we generated site-directed mutations at Cys4, Cys186, and Cys464 (Supplementary Fig