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I., Hjelle, B

This novel pathway reinforces the recent evidence that lysosomes do not function solely as recycling bins but are involved in numerous regulatory processes, such as mTORC1-mediated nutrient sensing, orchestrating transcriptional programs that control various metabolic and cellular events (Saftig & Klumperman, 2009

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Glucocorticoids: prednisone, prednisolone, and deflazacort have been used as the gold standard for the treatment of DMD for more than 30 years [102, 103]

This temporarily increases dopamine signalling, causing an energy spike

Intracellular Ca 2+ levels are further augmented by the inhibition of Ca 2+ reuptake into the endoplasmic reticulum due to the ATP depletion