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GSC23 tumor cells were cocultured with M0 microglia or microglia induced toward an M2-like state through either IL-4 (M2IL-4) or IL-13 (M2IL-13)

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The glutamine-dependent mTOR signalling pathway-activated enzymes carbamoyl-phosphate synthetase 2, aspartate transcarbamylase, and dihydroorotase (CAD) can then catalyse the incorporation of glutamine-derived nitrogen into pyrimidine precursors [60,61,62]

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Although endocannabinoids are potential mediators for healthy and diseased skin, it is believed to be premature to target pigmentation disorders using cannabinoids

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