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The unique microenvironmental and intrinsic cell properties of brain tumors have made them practically resistant to majority of conventional and cutting-edged therapies [3]
Beck, E

Van Luyn MJ, Muller M, Renes J et al (1998) Transport of glutathione conjugates into secretory vesicles is mediated by the multidrug-resistance protein 1

Nature 341 , 456458 (1989)

Cyanocobalamin is a little different

Taking massive "mega-doses" is usually less effective than taking a steady, moderate dose daily
