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10.3389/fchem.2023.1158198 Front Chem

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They are not approved by the FDA for human use outside of clinical trials

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Analysis of mRNA from the aortas of different groups showed that FOXO4-DRI effectively inhibited the increase of pro-inflammatory factors such as Il-1 , Il-6 , Cxcl15 , and Tnf- (Figure 2B)