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Individuals with CBS mutations will be slow to make glutathione.33 Flipping this around, individuals who have slow methylation cycle enzymes will have lower homocysteine levels

T H 17 cells are involved in host defence against extracellular pathogens, but also contribute to the pathogenesis of immune-mediated diseases such as MS

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Beyond direct lysosomal impairment, NPs further inhibit autophagic flux by interfering with the merger of autophagosomes and lysosomes, thereby blocking aggregate clearance