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Transcriptomic and proteomic analyses will be employed to identify genes and proteins regulated by kisspeptin-10 stimulation

However, in healthy human subjects, the Arg16 polymorphism is associated with enhanced agonist-mediated desensitization to vasodilatation, and the Glu27 polymorphism correlates with increased agonist-mediated responsiveness (Dishy et al., 2001)

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Transcriptomic analysis and qRT-PCR experiments revealed that their combination regulated AD-related pathways and genes more comprehensively, particularly affecting the Neuroactive ligand-receptor interaction and Calcium signaling pathway