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[PubMed] [Google Scholar] 83.Isgro A., Gaziev J., Sodani P., Lucarelli G

Based on preclinical (animal and cellular) data only, inhibition of NNMT by 5-Amino-1MQ is theorised to: Raise intracellular NAD+ levels Activate SIRT1 and other sirtuins (proteins linked to metabolic regulation) Reduce fat cell (adipocyte) size and proliferation Improve insulin sensitivity These effects have been demonstrated in mouse models (Neelakantan et al., 2019), but robust human clinical trial data are currently absent

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Across roughly six trials in more than 900 participants, an early shorter study suggested a promising signal, but the pivotal 24-week randomized, double-blind, placebo-controlled trial (METAOD006) did not reach statistical significance versus placebo, and the peptide added no benefit over an intensive diet-and-exercise regimen
