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NaHCO 3 : Not recommended except if there is refractory acidosis, weak recommendation, low quality evidence (2C)

Residues involved in carnitine and Na + coordination were evaluated using two electrode voltage-clamp electrophysiology, confirming Na + -dependent carnitine transport and the functional significance of these sites

M.-Y.et al (2020)

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This could explain why tirzepatide (which stimulates the GIP pathway in addition to GLP -1) can be administered at higher doses than semaglutide (which only stimulates GLP-1), without amplifying the side effects typical of GLP-1 agonists (nausea, vomiting)

doi: 10.1042/bsr20160244 82 MaiolinoG.RossittoG.CaielliP.BisogniV.RossiG
