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The 2025 Brunel study helps, but broader independent replication across multiple institutions is needed

Noradrenergic neurons dwelling in the locus coeruleus are sensitive to various pathological insults and become altered or malfunctional in many neurological disorders, including attention-deficit/hyperactivity disorders, sleep-associated disturbances 591 , congenital central hypoventilation syndrome, depression and anxiety, and in neurodegenerative diseases, including AD and PD 592,593

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