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One possibility, because efficient endocytosis also requires MOR phosphorylation at Thr376 and/or Thr379 (Lau et al., 2011), is that endomorphins are less efficacious for producing multisite phosphorylation involving these additional residues

Free Radic Biol Med 177:381390

The area under the curve (AUC) after 30 days of treatment of DMSO-treated MOLM-13- Cas9 cells expressing sgRNAs targeting ABC transporters is plotted against the AUC of drug treated cells

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