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In contrast to how RTAs prevented LDE adduct export inhibition following ferroptosis induction ( Figure S2D ) (36) or lipid peroxidation induction ( Figure 4F ), the inhibition of LDE-adduct export caused by 4-HNE was not altered by pre-treatment with PHOXN ( Figure 5E-F )

Romero A, Ramos E, Castellano V et al (2012) Cytotoxicity induced by deltamethrin and its metabolites in SH-SY5Y cells can be differentially prevented by selected antioxidants

On the premise that GSTs and associated detoxification pathways did not evolve to metabolize synthetic compounds, however, it is reasonable to assume that they must also function in endogenous metabolism, with the caveat that these conjugates are probably formed in small amounts and are rapidly turned over

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Makovac, E., Thayer, J

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