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While the PARS1 inhibitor halofuginone exhibited toxicity, its optimized derivative DWN12088 demonstrated improved safety and efficacy in preclinical models and is currently under clinical investigation for IPF [143]

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The groups received THC (1.5 mg/kg) daily, which reduced the mRNA expression of IL-6, NF-, and TNF-

Targeting the humaninintegrinTGF axis may offer therapeutic potential
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