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It was first identified in 1973 by Dr
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Immunity 45 , 3145 (2016)
In their later study, Vaillancourt and his colleagues demonstrated that 4-HNE was cytotoxic and could induce apoptosis in human osteoarthritic chondrocytes [84]
The body becomes less equipped to neutralize the oxidative load it faces daily and the effects become increasingly visible and felt
