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Theoretical concerns about chronic NNMT inhibition include effects on the metabolism of other quinolinium and methylpyridinium endogenous metabolites and on the broader cellular methylation landscape

Retrieved May 3, 2025, from (Notes that riboflavin is a key coenzyme in energy metabolism

Patients with gastrointestinal disorders such as Crohns disease, celiac disease, or those who have undergone gastrointestinal surgeries (including gastric bypass) often experience impaired B12 absorption

It is a small-molecule NNMT inhibitor

It participates directly in methylation reactions and is present in circulation and tissues

Our prior investigations have unveiled substantial correlations between NNMT genetic variants and resting energy expenditure (Zhu et al., 2016), as well as maximal oxygen uptake (Teperino et al., 2010) in the Chinese populace