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Some estimates suggest that as many as one in five older individuals are deficient in vitamin B12

Patients who have undergone gastric bypass or other bariatric procedures have surgically altered anatomy that reduces the absorptive surface area in the stomach and small intestine

Influences HPA axis regulation and cortisol dynamics: The hypothalamic-pituitary-adrenal (HPA) axis governs physiological stress responses through sequential CRH, ACTH, and cortisol release