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Ann Rep Med Chem 2007

PMID: 28546418

Vandenput L, Mellstrom D, Kindmark A, et al

Avoid exposure to extreme heat

Blockage of in vivo A42 production, i.e., using antisense oligonucleotides to genes of key proteins involved in the production of A42, leads to significant diminution of oxidative damage to brain, a conclusion that strengthens the notion that A42 oligomer-associated oxidative damage and subsequent neurotoxicity is a fundamental process in mouse models of AD and MCI brains

G.P., Glutathione reductase: regulation and role in oxidative stress, in Oxidative stress and the molecular biology of antioxidant defenses