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Comparison of the effects of acetyl L-carnitine and amantadine for the treatment of fatigue inmultiple sclerosis: results of a pilot, randomised, double-blind, crossover trial

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25 In two randomized placebo-controlled trials, totaling 1257 patients with diabetic neuropathy, Sima and colleagues failed to find any significant electrophysiological change in patients treated with 500 or 1,000 mg ALC, although a significant improvement in the vibration perception threshold was reported

Additionally, in the field of molecular biology, a large number of studies are still needed to elucidate the specific mechanism of action of LC and explain its therapeutic effects on neurological and psychiatric diseases