glutathione connected to cysteine metabolic circuitries: druggable targets in cancer Frontiers | Cysteine Depletion, a

PLoS ONE 11 , e0150961 (2016)

DATS administered intraperitoneally to mice elevated the total sulfane sulfur pool (persulfides and polysulfides) and increased the activity of enzymes involved in their metabolism in the liver and kidney [197,198]

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Transl Psychiatry 2 : e109 This article provides an excellent model, to demonstrate that impaired oligodendrocyte structure and function impacts neural circuitry leading to downstream effects related to emotionality in rodents and patients with mood disorders

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Specifically, TNF- can impair synaptic signaling, IL-1 can interfere with neurotransmitter regulation and synaptic plasticity, and ROS can directly damage neuronal membranes, proteins, and DNA