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In vitro , ICA effectively attenuated the IL-1 induced suppression of SLC7A11 and GPX4 expression in SW1353 cells, restored intracellular levels of ROS, lipid peroxides, and MDA, and significantly reduced erastin induced ferroptosis

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Notably, 4-HNE can activate the mitochondrial ROS-mediated AKT/NF-B signaling pathway and increase MMP2 production in VSMCs (123)

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It offers a multi-faceted approach to brain health, providing neuroprotection, preserving mitochondrial function, and ameliorating secondary injuries associated with both mild and severe Traumatic Brain Injury (TBI)