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Senolytic FOXO4-DRI can inhibit FOXO4 binding by disrupting the p53-FOXO4 interaction and selectively cause apoptosis via p53 nuclear exclusion in senescent cells and aging mouse models, which may be a promising approach for preventing senescence 11

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It has also shown success in Phase II trials for ophthalmic repair and dry eye

However, despite the excellent pharmacological properties of peptides, their poor physical and metabolic stability still present significant challenges for efficient delivery

Planning 3-month protocols Short-term focused goals