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In addition, oxidative stress extends beyond the lung, contribute to several of the systemic manifestations

Ciprofloxacin and nitrofurantoin were used as positive controls

Under normoxic conditions, HIF-1 is hydroxylated by the prolyl hydroxylase domain protein 2 (PHD2), and then it interacts with the von Hippel Lindau protein (VHL)
Overall, this study highlights the molecular mechanisms that underline cisplatin toxicity to APL cells, and provides insights into selection of novel targets and/or design of therapeutic agents to treat APL

Sulfoxidation of mercapturic acids derived from tri-and tetrachloroethene by cytochromes P450 3A: a bioactivation reaction in addition to deacetylation and cysteine conjugate -lyase mediated cleavage

10.1080/10408440500533208 [DOI] [PubMed] [Google Scholar] Gonzalez C
