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Reichheld et al., 2007

(vii) glutamine consumption by clear cell renal cell carcinoma in vitro leads to IL-23 secretion by macrophages and Tregs recruitment, possibly restraining antitumor immunity in humans too [189]

Phase I biotransformation seems to be enzymes that catalyzes oxidation, reduction or hydrolyze reactions, it usually converts substrates to more polar forms by introducing or unmasking a functional group (e.g., OH, NH2, or SH)
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[DOI] [PubMed] [Google Scholar] 35.Marengo B, Ciucis CD, Ricciarelli R, et al
