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Ferulic acid supplementation for six weeks at a dose of 1000 mg daily in a randomized, double-blind, placebo-controlled clinical trial resulted in significant reductions in total cholesterol, Low-Density Lipoprotein Cholesterol (LDL-C), triglycerides, and oxidative stress marker levels, followed by an increase in High-Density Lipoprotein Cholesterol (HDL-C)

J Korean Med Sci 2005;20(5):721-726

J Biol Chem 277, 4125441258 (2002)

PGC-1 Regulates ROS Defense It has been shown that oxidative stress increases the expression of PGC-1 [134]

Some treatments require for instance daily administration of high doses (800-1200 mg/day) for periods of 24-48 weeks

Barbosa et al
